I'm a heavy user of Google personalized desktop, well actually, it has just been renamed to identify with my personalized music player, it is now iGoogle. iGoogle is pretty amazing and if you are a heavy Google user it is one stop shopping.
On my iGoogle page, which has been personalized with the "beach theme," (with a geo-synchronized rising and setting sun), I've added the following gadgets: Google finance - listing stocks I'm watching, Gmail - showing all my new emails, Google Reader - showing all the new feed postings, Google Docs - where I keep a few documents that I want to be able to quickly reference at home and at work. If you used another email client, it can do that too. Pretty sophisticated once you get started and an easy way to monitor "everything" (Stocks, Email, News/Feeds, etc.) on one page.
The new name, however, is interesting.